What is DAXXIFY™?

DAXXIFY™ is the only long-lasting, peptide-powered frown line treatment. It is FDA-approved to smooth moderate to severe lines between the brows, with results lasting six to nine months. As a type of neuromodulator, DAXXIFY™ relaxes the facial muscles and blocks acetylcholine, the chemical responsible for activating muscles. This diminishes the appearance of wrinkles that form from repeated muscle contractions.

Dr Yael Halaas - on Good Day New York Talking All Things Beauty 2023

How is DAXXIFY™ different from other frown line treatments?

All frown line treatments contain botulinum toxin A, the protein responsible for helping smooth moderate to severe frown lines, and require a special ingredient to stabilize it. DAXXIFY™ is unique because it is the only formulation featuring a novel peptide as a stabilizer, meaning it does not contain human or animal byproducts.

What are the benefits of DAXXIFY™?

The most significant DAXXIFY™ benefit is its safety and efficacy. With more than twenty years of research, it was FDA-approved based on clinical trial data collected on more than 2,700 patients across different ages and with varying types of skin who received 4,200 treatments. 

One month after injections, 98% had little or no appearance of wrinkles. Half were entirely or nearly wrinkle-free at the injection area after six months, and some still noticed results nine months later. During clinical trials, researchers didn’t observe any treatment-related severe side effects, and there were no notable differences in how DAXXIFY™ performed for varying skin types.

Other DAXXIFY™ benefits include the following:

  • It lasts longer than any other neuromodulator
  • Smooths crow’s feet, frown lines, and horizontal forehead lines
  • Can prevent future wrinkles from developing by reducing repeated muscle movement
  • Convenient and comfortable, making it the perfect lunchtime treatment
  • Minimally-invasive
  • No downtime

Am I a good candidate for DAXXIFY™?

DAXXIFY™ is suitable for a wide variety of candidates. If you have noticeable dynamic wrinkles around your eyes, between your brows, and on your forehead, DAXXIFY™ could be the perfect solution.

Candidates should be over eighteen and in generally good health. DAXXIFY™ candidates should not:

  • Have active skin disease or infection at the injection sites
  • Have a history of bleeding disorders
  • Follow injections with laser or light treatments, microdermabrasion, or chemical peels until cleared to do so
  • Be pregnant or breastfeeding
  • Have a neurological disorder


DAXXIFY™ is best for people who have tried other injectables. That’s because the results can last up to twice as long as other neuromodulators, meaning you cannot undo an outcome you dislike.

Yael Halaas MD

DAXXIFY™ procedure results

DAXXIFY™ uses a small needle, so the injection feels like a pinch and is not painful. However, if you’re concerned about discomfort, we may ice the area or apply a topical numbing cream. 

Treatment with DAXXIFY™ requires minimal downtime, and you can return to your daily routine immediately. Results appear as early as the next day after treatment, typically within two days, but you should see noticeable results within two weeks. 

In terms of side effects, you may experience mild injection-related bruising, which heals within a few days. The area around the injection site could:

  • Swell
  • Turn red
  • Cause pain or tenderness from the injection itself

However, these side effects are typically minor and resolve after a few hours or days.

Written by Dr. Halaas

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